Abstract

This study examined the hypoglycaemic effect of Entada abyssinica leaves on alloxan induced diabetes mellitus. The experiment was conducted using 12 mice for a period of 5 weeks divided into three groups of four mice each. Group 1 was un-induced (positive control), group 2 was induced fed on non-supplemented diet (negative control) and group 3 was induced fed Entada abyssinica (tawatsa) leaves supplementation (5% of the diet). The mice were made diabetic by intra-peritoneal injection of 180 mg/kg b.wt with alloxan. Fasting blood glucose was measured seven days after diabetic induction to determine the severity of blood glucose elevation. Similarly fasting blood glucose was measured every week to evaluate the hypoglycaemic effect of the supplement. E. abyssinica effects on serum glucose level and malondialdehyde levels were significant in diabetic treated compared to diabetic control (6.7±0.81 vs. 16.2±1.6 mmol/L and 10.08±0.61 vs. 16.44±3.00 μmol/L at p<0.05), respectively. The result of this research suggests that E. abyssinica has hypoglycemic and antioxidant effect on allaxon induced diabetic mice.

Keywords:

Alloxan, antioxidant, diabetes mellitus, Entada abyssinica, hypoglyceamic effect, oxidative stress,

References

Competing interests

The authors have no competing interests.

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The authors have no competing interests.