Abstract

Evaluating electrocardiographic parameters in healthy dogs anesthetized with ketamine-propofol combination (ketofol) and medetomidine, acepromazine and acepromazine-morphine as preanesthetic agents. Six healthy adult mix dogs (3 male, 3 female) weighing 17.8±4.8 were include the study. Normal saline, medetomidine 20 μg/kg, acepromazine 0.05 mg/kg or acepromazine 0.05 mg/kg plus morphine 0.5 mg/kg were administered intramuscularly as premedication. Thirty minutes after premedication, rapid bolus intravenous injections of 0.4 mL/kg, 1:1 single syringe ketamine-propofol combination, was administrated for induction. Anesthesia was maintained with isoflurane for 1 h. Electrocardiographic examinations were made before premedication and others at 0, 5, 10, 15, 30 and 60 min after induction. Heart rate, electrical axis of the heart, duration of P, QRS and T waves, length of PR-QT and ST segments, active potential of P, R and T waves studied for any possibility of changes. Evaluation of heart rate in this study showed a significant increase in saline and a significant decrease in medetomidine groups. There were some significant differences in P wave duration and QRS complexes but irregular figure or deviated cardiac axis were not seen in recorded ECGs. The study results revealed prolonged atrial depolarization in all study groups especially in medetomidine and acepromazine-morphine groups. The other parameters were not shown any discussable significant differences.

Keywords:

Dog, ECG, ketofol,

References

Competing interests

The authors have no competing interests.

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The authors have no competing interests.