Research Article | OPEN ACCESS
Mathematical Equations Applicability for Data Interpretation of Pharmaceutics Nano Sizing by Rapid Expansion of Supercritical Solvent Process
1Fatemeh Zabihi and 2Maryam Otadi
1Department of Chemical Engineering, Ayatollah Amoli Science and
Research Branch, Islamic Azad University, Amol, Iran
2Department of Chemical Engineering, Tehran Central Branch,
Islamic Azad University, Tehran, Iran
Research Journal of Applied Sciences, Engineering and Technology 2013 13:3481-3488
Received: May 19, 2012 | Accepted: June 08, 2012 | Published: April 15, 2013
Abstract
A numerical and theoretical method has been applied to approve the empirical data and understand the operational variables influence on the RESS processed Ibuprofen tiny particles characteristics. Through the RESS method, Ibuprofen nano-particles were produced. The pressure of dissolution cell and the temperature of expansion device were considered as the experimental variables and the impressibility of the particle size distribution by the variables was investigated. The compatibility of 3 different 2-dimensional equations with the experimental results was tested and compared. As a result, 2-D Spline equation showed the best accordance with the experimental data. A 2-D Lagrange model was also fitted on the empirical data adequately. However the Spline calculated results showed a more reliability, especially at the high pressure ranges, where the function (mean particles size) is intensively dominated by the supercritical solution characteristics.
Keywords:
Lagrange, mathematical data correlation, spline, supercritical fluid technology,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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