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Abstract
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Article Information:
Effects of Aqueous Extracts (Leaves and Stem) of Vitex doniana on Carbon Tetrachloride Induced Liver Injury in Rats
D.B. James, O.A. Owolabi, M. Bisalla and H. Jassium
Corresponding Author: Dorcas B James
Submitted: 2010 April, 05
Accepted: 2010 April, 22
Published: 2010 June, 20 |
Abstract:
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Effects of aqueous extracts of leaves and stem of Vitex doniana on carbon tetrachloride induced liver
injury in rats was assessed. Thirty- six (36) albino rats were divided into six groups of 6 animals each by the
randomized random design method, each were allowed food and water ad libidium. Group I (control) was given
olive oil, while the rest groups were injected intraperitoneally with a single dose of CCl4 (1 mg/kg) as a 50%
(v/v) solution in olive oil and all animals fasted for 36 h, this was repeated every week for a period of four (4)
week after 36 h of induction, group III, IV, V and VI were given extracts of Vitex doniana at concentration dose
of 100 and 200 mg/kg body weight. At the end of 4 weeks, weight change and histological sections of organs
were examined. There was significant (p<0.05) reduction in percentage change in w eights in rats treated with
CCl4 when compared to the control-group. Significant (p<0.05) increase in percentage change in liver, kidney
and spleen in animals treated with CCl4 was observed compared with control group and all animal administer
Vitex doniana. Histological section of the organs shows that the levels of hepatic, renal and lymphatic damage
were higher in CCl4 treated rats than those rats supplemented with aqueous extract of Vitex doniana. These findings suggested that aqueous extract of Vitex doniana may have anti-hepatotoxic effect against CCl4-induced
liver injury in rats and that this effect is concentration dependent.
Key words: Carbon tetrachloride, hepatoprotective, histopathology, liver damage, Vitex doniana, ,
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Cite this Reference:
D.B. James, O.A. Owolabi, M. Bisalla and H. Jassium, . Effects of Aqueous Extracts (Leaves and Stem) of Vitex doniana on Carbon Tetrachloride Induced Liver Injury in Rats. British Journal of Pharmacology and Toxicology, (1): Page No: 1-5.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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