Research Article | OPEN ACCESS
Research on Water Bath Dynamic Cross-linking Properties of Bone Scaffold Made of Gelatin and Sodium Alginate
Lulu Zheng, Yuanyuan Liu, Feifei Yan, Weihua Chen, Fuhua Zhang and Qingxi Hu
Rapid Manufacturing Engineering Center, Shanghai University, Shanghai 200444, P.R. China
Advance Journal of Food Science and Technology 2013 10:1318-1321
Received: May 16, 2013 | Accepted: July 05, 2013 | Published: October 05, 2013
Abstract
This study presents a novel water bath dynamic cross-linking method which involves cross-linking process when the bone scaffold is being manufactured. Biomaterial possesses good biocompatibility, but possesses poor mechanical properties. Thus, the uncross-linked bone scaffold usually degrades rapidly, contracts easily and can’t meet the requirements of scaffold for tissue engineering. After being cross-linked by $Ca^{2+}$ ions, scaffold made of Gelatin and Sodium Alginate (SA), one kind of gel-type scaffolds, can present much better mechanical properties. However, $Ca^{2+}$ ions can react with SA solution and the gel can limit the flowing of $Ca^{2+}$ ions in the entire system, hence making cross-linking process uneven for the inner part. Applying the novel approach, the designed experiment verifies the scaffold can posses higher porosity, contain more water, has lower degradation rate and better mechanical properties.
Keywords:
Cross-linking, $Ca^{2+}$ ions, mechanical properties, water bath dynamic,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2042-4876
ISSN (Print): 2042-4868 |
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