Research Article | OPEN ACCESS
Changes in the Spermatogenesis and Histology of Testis in Rat Treated with Matricaria recutita
1Fereshteh Javadian, 2Jasem Estakhr, 1Jina Khayatzade, 3Abbas Jamshidiyan and 4Dariush Saadati
1Department of Biology, Faculty of Science, Mashhad Branch, Islamic Azad University, Mashhad, Iran
2Department of Biology, Faculty of Science
3Department of Photobiology
4Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
Research Journal of Applied Sciences, Engineering and Technology 2013 3:1036-1040
Received: June 28, 2012 | Accepted: August 08, 2012 | Published: January 21, 2013
Abstract
The present study investigates the anti-spermatogenic potential of ethanolic extract of Matricaria recutita a plant belonging to Asteraceae family. The effects of an ethanolic extract of the Matricaria recutita on spermatogenesis, histology of testis and level of testosterone were examined in control and experimental groups. Results showed that Matricaria recutita extract did not cause any changes in body weight, but significantly decreased the testis weight (p<0.05). The sperm motility and the epididymal sperm counts and serum testosterone levels of rats treated for 56 days were significantly reduced (p<0.05). There were various degrees of damage to the seminiferous tubules including; disorganized germinal epithelium, degenerated and necrotic cells and reduction in the diameter of seminiferous tubules. It can be concluded that that alcoholic extract of Matricaria recutita has anti-spermatogenic properties in adult male rats through its compounds and it may be useful to regulate spermatogenesis and male fertility.
Keywords:
Anti-spermatogenic, Matricaria recutita, rat, testis,
Competing interests
The authors have no competing interests.
Open Access Policy
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Copyright
The authors have no competing interests.
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ISSN (Online): 2040-7467
ISSN (Print): 2040-7459 |
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